Russian Covid-19 vaccine Sputnik V effective against omicron, developers say

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Moscow: Russia’s Covid-19 vaccine, Sputnik V, has twice as many virus-neutralizing antibodies against the Omicron variant as the Pfizer vaccine, its developers said Wednesday based on a pre-printed study.

“A unique independent comparative study conducted at the National Institute of Infectious Diseases Lazzaro Spallanzani (Italy) by a joint team of researchers from the Institute and the Gamaleya Center showing that 2 doses of Sputnik V provide geometric mean titers more than 2 times higher (GMT) of virus-neutralizing antibodies against the Omicron variant of COVID than 2 doses of Pfizer vaccine (2.1 times higher overall and 2.6 times higher 3 months post-vaccination),” said the vaccine developers, Gamaleya Center and Russian Direct Investment Fund, in a statement.

“Based on the data collected by the Spallanzani Institute and the results of previous studies, heterologous booster (“mix & match”) with Sputnik Light is the best solution to increase the effectiveness of other vaccines and extend the period of recall protection because the optimal configuration of the adenoviral platform provides better protection against Omicron and other mutations..”, read the statement.

The developers also said that Sputnik Light has already shown strong results as a booster in “mix and match” trials in Argentina. A combination of Sputnik Light with vaccines produced by AstraZeneca, Sinopharm, Moderna and Cansino, conducted in 5 provinces (city and province of Buenos Aires, as well as Córdoba, La Rioja and San Luis) demonstrated that Sputnik Light induces stronger antibodies and T-cell response compared to a homologous regimen (two injections of the same vaccine).

“The joint study confirmed the results obtained in our separate study published in December 2021. The strong scientific data proves that Sputnik V has higher virus neutralizing activity against Omicron compared to other vaccines and will play a major role in the fight against world against this new contagious virus. variant,” said Alexander Gintsburg, director of the Gamaleya Center.

“As the duration of vaccine protection is essential to avoid frequent boosters, the authors of another study in Argentina noted that protection against coronavirus remains stable after vaccination with the Russian vaccine Sputnik V due to the maturation of the antibodies, which enhances the potency of antibodies against the virus to evade mutations,” the researchers said in the paper.

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